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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-99a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell lines SO-RB50 and Y79
Methods CCK-8 assay, colony formation assay, apoptosis assay, transwell assay, transfection, qRT-PCR, Western blot
Expression pattern up-regulated
Functional description The anti-tumor activities of curcumin on Rb cells appeared to be via up-regulation of miR-99a, and thereby inhibition of JAK/STAT pathway.
PubMed ID 30526546
Year 2018
Title Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway.
Drug-related ncRNA YES (curcumin)

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